Scientists have uncovered a powerful genetic switch that helps some of the body’s most important immune cells grow up properly and keep our organs healthy. The switch, called MafB, guides immature precursor cells as they develop into macrophages, the body’s clean-up and repair crew that removes pathogens, clears debris, recycles iron, and supports tissue function. When MafB is missing, these cells
Scientists at Rice University have produced the first full, dye-free molecular atlas of an Alzheimer’s brain. By combining laser-based imaging with machine learning, they uncovered chemical changes that spread unevenly across the brain and extend beyond amyloid plaques. Key memory regions showed major shifts in cholesterol and energy-related molecules. The findings hint that Alzheimer’s is a whole
That photogenic cup of bubble tea may come with hidden downsides. Tapioca pearls made from cassava can absorb heavy metals like lead, and in large amounts they may slow digestion or even cause blockages. The drink is often loaded with sugar—sometimes more than soda—raising risks for cavities, obesity, diabetes, and fatty liver disease. There are even reports linking frequent consumption to kidney
Scientists at Oregon State University have engineered a powerful new nanomaterial that zeroes in on cancer cells and destroys them from the inside out. Designed to exploit cancer’s unique chemistry—its acidity and high hydrogen peroxide levels—the tiny iron-based structure sparks not one but two intense chemical reactions, flooding tumors with cell-damaging oxygen molecules. This dual attack overw
Struggling to fall asleep and stopping breathing at night may be a far riskier combo than previously thought. In a study of nearly a million veterans, researchers found that having both insomnia and sleep apnea dramatically raises the risk of hypertension and heart disease. The two conditions don’t just coexist—they interact in ways that intensify strain on the heart. Addressing sleep problems ear
Scientists are taking a closer look at the pill forms of Wegovy and Ozempic. In an animal study, the ingredient SNAC, which helps semaglutide survive the stomach and enter the bloodstream, was associated with changes in gut bacteria, inflammation markers, and a brain linked protein. The research does not show harm in people, but it raises new questions about the long term effects of daily exposure
Novartis becomes the second company to settle after being accused of reaping rewards from a racist medical system.
Scientists have built a massive cellular atlas showing how aging reshapes the body across 21 organs. Studying nearly 7 million cells, they found that aging starts earlier than expected and unfolds in a coordinated way throughout the body. About a quarter of cell types change in number over time, and many of these shifts differ between males and females. The research also highlights shared genetic
Drug-resistant bacteria are becoming harder to treat, pushing scientists to look for new antibiotic targets. Researchers have now discovered that several unrelated viruses disable a key bacterial protein called MurJ, which is essential for building the bacterial cell wall. High-resolution imaging shows these viral proteins lock MurJ into a single position, stopping cell wall construction and leadi
Scientists at Texas A&M are turning an everyday pick-me-up into a high-tech medical switch. By combining caffeine with CRISPR gene editing, researchers have created a system that allows cells to be programmed in advance — and then activated simply by consuming a small dose of caffeine from coffee, chocolate, or soda. The approach, known as chemogenetics, lets scientists precisely turn gene-edi
Kennedy adds two new members to the CDC's vaccine advisory committee
Minnesota hospitals and clinics participating in a controversial U.S. drug discount program reaped at least $1.34 billion in revenue in 2024.
SEC filings show that, at least for some drugmakers, "most-favored nation" drug pricing deals with President Trump last three years.
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From new hires to departures, promotions and transfers, here are the latest comings and goings in the pharmaceutical industry.
Several Big Pharmas have introduced their own podcasts to advance corporate branding efforts, while health-focused nonprofits have found in podcasts an effective awareness-raising tool with a relatively low barrier of entry in terms of production costs.
“The surgeon general is not a wellness influencer,” writes former Surgeon General Jerome Adams of Casey Means.
FDA Commissioner Marty Makary defended the agency’s recent rejections of rare disease drugs and top agency official Vinay Prasad
In a Worker Adjustment and Retraining Notification Act alert filed this week, Merck revealed that it is laying off 147 staffers at a vaccine manufacturing plant in Durham. The cuts are a result of Merck's decision to end production of Gardasil and Gardasil 9 at the site "because of the recent worldwide reduction in demand for the product," according to the WARN letter.
Researchers found that cutting two amino acids common in animal protein—methionine and cysteine—made mice burn significantly more energy. The boost in heat production was nearly as powerful as constant exposure to cold temperatures. The mice didn’t eat less or exercise more; they simply generated more heat in their beige fat. The discovery hints that diet alone might activate the body’s calorie-bu