Brain inflammation may be driving compulsive behavior
For years, compulsive behaviors have been viewed as bad habits stuck on autopilot. But new research in rats found the opposite: inflammation in a key decision-making brain region actually made behavior more deliberate, not more automatic. The change was linked to astrocytes, brain support cells that multiplied and disrupted nearby circuits. The discovery hints that some compulsive behaviors may ar
Exercise may be one of the most powerful treatments for depression and anxiety
A sweeping review of global research suggests that exercise—especially aerobic activities like running, swimming, and dancing—can be one of the most powerful ways to ease depression and anxiety. Across tens of thousands of people aged 10 to 90, exercise consistently reduced symptoms, often matching or even outperforming medication and talk therapy.
Scientists discover the enzyme that lets cancer rapidly rewire its DNA
Researchers have uncovered the enzyme behind chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers. The enzyme, N4BP2, breaks apart DNA trapped in tiny cellular structures, unleashing a burst of genetic changes that can help tumors rapidly adapt and resist therapy. Blocking the enzyme dramatically reduced this genomic destruction in cancer cells.
STAT+: Kennedy says he’ll act on legal challenge to ultra-processed foods
Kennedy and his MAHA allies are increasingly focused on food issues as the midterms approach.
STAT+: Exit of CDC’s acting director highlights agency’s lack of leader
The lack of a Senate-confirmed leader is deepening the turmoil at the CDC.
This planet friendly diet could cut your risk of early death by 23%
A major new study suggests that eating the Nordic way could help you live significantly longer—while also helping the planet. Researchers from Aarhus University found that people who closely followed the 2023 Nordic dietary guidelines had a 23% lower risk of death compared to those who didn’t.
Large study finds no link between mRNA COVID vaccine in pregnancy and autism
Researchers tracked more than 400 toddlers to see whether mRNA COVID-19 vaccination during or just before pregnancy was linked to autism or developmental delays. After detailed assessments of speech, motor skills, behavior, and social development, they found no meaningful differences between vaccinated and unvaccinated groups. Experts say the results provide strong reassurance about vaccine safety
AI uncovers the hidden genetic control centers driving Alzheimer’s
Scientists have created the most detailed maps yet of how genes control one another inside the brains of people with Alzheimer’s disease. Using a powerful new AI-based system called SIGNET, the team uncovered cause-and-effect relationships between genes across six major brain cell types, revealing which genes are truly driving harmful changes. The most dramatic disruptions were found in excitatory
Stop eating 3 hours before bed to improve heart health
A simple shift in your evening routine may give your heart a measurable boost. In a new study, adults who stopped eating and dimmed the lights three hours before bed and extended their overnight fast by about two hours saw improvements in blood pressure, heart rate, and blood-sugar control — without cutting calories.
Scientists find nerves actively fuel pancreatic cancer
Scientists have uncovered a hidden partnership between pancreatic cancer and the nervous system. Support cells in the pancreas lure nerve fibers, which then release signals that accelerate early cancer growth. This creates a self-sustaining loop that helps tumors take hold. Blocking the nerve activity significantly reduced tumor growth in experiments, suggesting a new treatment strategy.
Massive study finds most statin side effects aren’t caused by the drugs
A massive review of 23 randomized trials found that statins do not cause the vast majority of side effects listed on their labels. Memory problems, depression, sleep issues, weight gain, and many other symptoms appeared just as often in people taking a placebo. Only a few side effects showed any link to statins — and even those were rare.
This breakthrough could finally unlock male birth control
Scientists at Michigan State University have uncovered the molecular “switch” that powers sperm for their final, high-speed dash toward an egg. By tracking how sperm use glucose as fuel, the team discovered how dormant cells suddenly flip into overdrive, burning energy in a carefully controlled, multi-step process. A key enzyme, aldolase, helps convert sugar into the burst of power needed for fert
The human exposome could change everything we know about disease
Scientists are launching an ambitious global effort to map the “human exposome” — the lifelong mix of environmental and chemical exposures that drive most diseases. Backed by new partnerships with governments, UNESCO, and international science advisory bodies, the initiative is rapidly expanding across continents. Powered by AI and advanced data tools, the movement seeks to shift medicine beyond g
Scientists discover a hidden gut bacterium linked to good health
A global study has uncovered a mysterious group of gut bacteria that shows up again and again in healthy people. Known as CAG-170, these microbes were found at lower levels in people with a range of chronic diseases. Genetic clues suggest they help digest food and support the broader gut ecosystem. Researchers say the discovery could reshape how we measure and maintain gut health.
STAT+: In court, AAP argues Kennedy’s HHS made unlawful changes to vaccine policies
After a day of oral arguments in a packed courtroom, a Boston federal judge did not rule from the bench on a lawsuit from AAP against HHS focused on vaccines.
STAT+: FDA rejects rare disease therapy from Disc Medicine, early recipient of commissioner’s voucher
The FDA has rejected a rare disease therapy from Disc Medicine, an early recipient of a commissioner's voucher from the agency.
Major shakeup underway at HHS as White House braces for midterms
Several senior officials are exiting RFK Jr.'s department amid an effort to focus on drug pricing and food issues.
STAT+: Up and down the ladder: The latest comings and goings
From new hires to departures, promotions and transfers, here are the latest comings and goings in the pharmaceutical industry.
STAT+: Pediatricians confront HHS in vaccine showdown
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STAT+: Pharmalittle: We’re reading about Lilly bulking up on weight-loss drugs, scrutiny of a 340B contractor, and more
And other pharma news from the Pharmalot campus today